The Los Angeles Rams beat the San Francisco 49ers 27-24 in Week 3 despite missing Cooper Kupp, Puka Nacua and multiple offensive linemen. However, they are still a three-point underdog in Week 4 NFL odds for their road game against the Chicago Bears. Chicago is coming off a 21-16 loss to the Colts and has struggled with a shaky offensive line all season, while the Rams have only had four sacks and nine quarterback hits all season. Who will win in the trenches for Bears vs. Rams? And how should you handle all 16 NFL spreads? Understanding NFL matchups and using NFL betting trends to make an informed decision is key to successful Week 4 NFL score predictions. So before you make any Week 4 NFL picks, you should check out our NFL spread, over-under and moneyline predictions powered by the self-learning SportsLine AI.
Built by SportsLine’s data science team using cutting-edge artificial intelligence and machine learning technology, AI predictions and AI ratings are generated for each game. AI predictions are determined by statistically learning from historical data for each team and quantitatively rating the strength of the opponent’s defense by assigning it a numerical value out of 100, called a Matchup Score.
Once a prediction is formulated, an AI rating is generated using the prediction, match score and market odds. For example, if a team has a weak defense, the prediction differs from the line and the odds are in your favour, you may see an A rating on an over bet.
Plus, SportsLine AI is SportsLine’s first fully automated prediction model, which is continually updated with the latest available data to help you find the biggest discrepancies in lines. Last season, SportsLine’s AI PickBot hit 1,674 4.5- and 5-star prop picks, a difference that anyone who’s used the tool can attest to.
For Week 4 NFL betting, AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. Here you can see only the AI predictions for Week 4 NFL schedule.
Top NFL AI picks for Week 4
AI PickBot is predicting the Jaguars to cover as 6.5-point away underdogs against the Texans after analyzing all of the matchups in Week 4. Jacksonville is off to an 0-3 start and is coming off a humiliating 47-10 loss to the Bills on Monday Night Football. The loss puts Doug Pederson in a tough position, but he has a chance to get back on track with a division win in Week 4.
Houston also suffered a blowout loss in Week 3, losing 34-7 to the Vikings in a game where the Texans were 1.5-to-1 favorites on the road. They’re currently favored to beat Jacksonville by 6.5-to-1, but the Jaguars have beaten the Texans in two of their past three meetings, including a 24-21 win at Houston last year in which Trevor Lawrence threw for 364 yards. Our AI pick bot also expects Joe Mixon’s high ankle sprain to play a role, giving Houston an average win of 23-21 and an A-grade pick with Jacksonville covering. See more Week 4 football predictions and football picks at SportsLine.
How to make your Week 4 NFL picks
Additionally, AI PickBot generated 11 A-rated picks for Week 4. Before you place any NFL bets yourself in Week 4, you should take a look at AI PickBot’s picks, which you can find exclusively at SportsLine.
Who will win and cover each NFL game in Week 4, and which A-rated picks should you target? Visit SportsLine now for the top NFL picks against the spread, over-under and money line, all powered by the all-new SportsLine AI PickBot, which hit the mark on 1,674 top-rated picks last season.
